spacerg.gif (807 bytes)

DLw.jpg (4907 bytes)

spacerg.jpg (289 bytes)

spacerg.gif (807 bytes)

The Magnesium Lottery

Magnesium deficiency is common and deadly. Diuretics, heart conditions, exercise, and the ECA stack influence magnesium status.

spacerg.gif (807 bytes)

Contents

Page 1
A bunch of scary studies.
Page 2
Big brother to the rescue (sort of).
Dieters, athletes, and ECA.

Page 3
Diuretics and magnesium.
Page 4
The turf war.
Page 5
Safety & bioavailability.

Warning: The nutrients discussed in this section can greatly improve the health of people with heart failure, hypertension, etc. But before taking these supplements, you should talk with your doctor so that he can monitor you and adjust the dosage of your prescription drugs.

Diuretics And Magnesium

My mother has congestive heart failure. Although I told her (many times) about the benefits of supplements, she did not want to take them: "I have to take a handful of drugs everyday and I don't want to take ANY more pills" was her usual response. Trips to the emergency room occurred frequently. And, as if that wasn't bad enough, the diuretics (water pills) that she was getting from her doctor were depleting her potassium and endangering her life.

The best that several doctors and a heart specialist could do was to give her potassium-sparing diuretics and higher doses of potassium. This did no good because she was not retaining the potassium. Eventually, her potassium got so low that she almost died -- I found her on the floor unable to move. Another trip to the emergency room.

This traumatic experience convinced my mother that the doctors were unable to get a handle on this potassium problem. She didn't want to end up paralyzed again, so she agreed to take whatever I thought would help this potassium problem -- as long as it involved a "reasonable" amount of pills (I take a LOT of supplements).magnesium, mineral, congestive heart failure

That night I did a MEDLINE computer search of the medical literature. For the life of me, I can't imagine why the doctors and the specialist (expensivist?) couldn't figure the problem out -- the reason why my mother was unable to retain potassium was easy to find. In fact, there is so much research on this that it's hard not to trip over it. You do NOT have to be Sherlock Holmes, dig? Here are a few clues:

spacerg.gif (807 bytes)

Written
Aug 2000
Last Update
Aug 2000

magnesium, mineral, congestive heart failure

A medical article titled "Refractory potassium repletion. A consequence of magnesium deficiency" explains how diuretics flush a lot more than potassium out of your system -- and if (when) you get low in magnesium, you will be unable to retain potassium:

"Patients with hypertension and with congestive heart failure appear to be at special risk for magnesium depletion because diuretics are commonly prescribed in treatment . . .  Experimental and clinical observations support the view that uncorrected magnesium deficiency impairs repletion of cellular potassium . . . consideration should be given to treating hypokalemic [low potassium] patients with both magnesium as well as potassium to avoid the problem of refractory potassium repletion due to coexisting magnesium deficiency" (19). [emphasis added]

Consideration???  I nominate that for the understatement of the year award. Lets see . . . hmm . . . If the patient doesn't take magnesium supplements, she will die. Hmm . . . Maybe we should give them thar suppulments some "consideration." What do you think, Jethro?

magnesium, mineral, congestive heart failure

I realize that medical professionals are busy and abstracts contain up to 250 words,magnesium, mineral, congestive heart failure but just the TITLE of this article should have given the doctors and the highly paid specialist a clue: "Potassium/magnesium depletion in patients with cardiovascular disease" explains how 43% of heart patients are at risk of dying (sudden death) from magnesium deficiency:

"below normal muscle magnesium levels have been found in 43 percent of congestive heart failure patients receiving diuretics. Magnesium is important for maintenance of cell potassium . . . an increased risk of sudden death demands that potassium and magnesium deficiencies be treated promptly and that repletion of both electrolytes be considered" (21). [emphasis added]

They said "demands." Right on! Oops, just as I was about to say that it's nice to see scientists with the guts to say it straight, they wimp out and use the word "considered." Hey guys, get real -- it's death or magnesium. What's to consider?

magnesium, mineral, congestive heart failure

"Introduction: magnesium -- coming of age" discusses how the patients serum magnesium level can be misleading. Do the research scientists have to hit doctors over the head with sledgehammers? Every heart patient with sound kidneys should be taking magnesium supplements:

"Clinical and research evidence continues to accumulate that magnesium deficiency likewise contributes to triggering ventricular ectopic activity and sudden cardiac death ... magnesium depletion can coexist with a low-normal to normal serum magnesium level ... The most frequent causes of magnesium depletion in cardiovascular medicine are diuretic drugs" (22-NA).

So, obviously, I gave my mother magnesium supplements and (SURPRISE, SURPRISE) her potassium level went up and the problem was solved. This has over a decade of documentation in the medical literature. Why is magnesium STILL underutilized? If I were not self-educated, my mother probably would not have survived. In addition to fixing her potassium problem, the magnesium supplements also made my mother feel better -- which is not too surprising since magnesium also improves left ventricular function and exercise tolerance (28).

Fortunately, this experience changed her attitude about pill taking and supplements and she asked me what else she should take. I showed her TWO DECADES of research in medical journals about supplements that are extremely safe and effective for her heart problems. Based on the medical literature, in addition to her prescription drugs, she began taking Coenzyme Q10, Carnitine, Taurine, etc. (I will discuss these supplements in a separate post.) Before this she was in the emergency room several times a year. Since the addition of the supplements more than FIVE YEARS AGO, she has never had to go to the emergency room.

    nextpage.gif (1952 bytes)
Next Page

spacerg.gif (807 bytes)
spacerg.gif (807 bytes)

Home
DrumLib's Posts
Vitamin Price Comparison
Document Retrieval
Dictionary
FAQ
Links
E-mail
Terms & Privacy
TOC

References

Get full-text medical articles cheap!
Selma's Document Retrieval Service

1.) Durlach J, Bara M, Guiet-Bara A "Magnesium level in drinking water and cardiovascular risk factor: a hypothesis" Magnesium 1985, Vol 4 (1), Pg 5-15. PMID: 0004033205.

2.) Marier JR and Neri LC "Quantifying the role of magnesium in the interrelationship between human mortality/morbidity and water hardness" Magnesium 1985, Vol 4 (2-3), Pg 53-9. PMID: 0004046646.

3.) Marx A and Neutra RR "Magnesium in drinking water and ischemic heart disease" Epidemiol Rev 1997, Vol 19 (2), Pg 258-72. PMID: 0009494787.

4.) Rubenowitz E, Axelsson G, Rylander R "Magnesium in drinking water and death from acute myocardial infarction" Am J Epidemiol 1996, Vol 143 (5), Pg 456-62. PMID: 0008610660.

5.) Yang CY "Calcium and magnesium in drinking water and risk of death from cerebrovascular disease" Stroke 1998, Vol 29 (2), Pg 411-4. PMID: 0009472882.

6.) Yang CY and Chiu HF "Calcium and magnesium in drinking water and the risk of death from hypertension" Am J Hypertens 1999, Vol 12 (9 Pt 1), Pg 894-9. PMID: 0010509547.

7.) Yang CY, Chiu HF, Cheng MF, Tsai SS, Hung CF, Lin MC "Esophageal cancer mortality and total hardness levels in Taiwan's drinking water" Environ Res 1999, Vol 81 (4), Pg 302-8. PMID: 0010581108.

8.) Yang CY, Chiu HF, Cheng MF, Tsai SS, Hung CF, Tseng YT "Magnesium in drinking water and the risk of death from diabetes mellitus" Magnes Res 1999, Vol 12 (2), Pg 131-7. PMID: 0010423708.

9-BK.) Dr. Michael Colgan "Optimum Sports Nutrition: Your Competitive Edge" New York: Advanced Research Press 1993, ISBN: 0962484059.

10.) Joborn H, Akerstrom G, Ljunghall S "Effects of exogenous catecholamines and exercise on plasma magnesium concentrations" Clin Endocrinol (Oxf) 1985, Vol 23 (3), Pg 219-26. PMID: 0004075536.

11.) Kynast-Gales SA and Massey LK "Effect of caffeine on circadian excretion of urinary calcium and magnesium" J Am Coll Nutr 1994, Vol 13 (5), Pg 467-72. PMID: 0007836625.

12.) Altura BM and Altura BT "New perspectives on the role of magnesium in the pathophysiology of the cardiovascular system. I. Clinical aspects" Magnesium 1985, Vol 4 (5-6), Pg 226-44. PMID: 0003914580.

13.) Ma J, Folsom AR, Melnick SL, Eckfeldt JH, Sharrett AR, Nabulsi AA, Hutchinson RG, Metcalf PA "Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid arterial wall thickness: the ARIC study. Atherosclerosis Risk in Communities Study" J Clin Epidemiol 1995, Vol 48 (7), Pg 927-40. PMID: 0007782801.

14.) Paolisso G and Barbagallo M "Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium" Am J Hypertens 1997, Vol 10 (3), Pg 346-55. PMID: 0009056694.

15.) Altura BM and Altura BT "Cardiovascular risk factors and magnesium: relationships to atherosclerosis, ischemic heart disease and hypertension" Magnes Trace Elem 1991-1992, Vol 10 (2-4), Pg 182-92. PMID: 0001844551.

16.) Abraham AS "Potassium and magnesium status in ischaemic heart disease" Magnes Res 1988, Vol 1 (1-2), Pg 53-7. PMID: 0003079203.

17.) Gettes LS "Electrolyte abnormalities underlying lethal and ventricular arrhythmias" Circulation 1992, Vol 85 (1 Suppl), Pg I70-6. PMID: 0001728508.

18-NA.) Dawson R Jr, Tang E, Shih D, Hern H, Hu M, Baker D, Eppler B "Taurine inhibition of iron-stimulated catecholamine oxidation" Adv Exp Med Biol 1998, Vol 442 Pg 155-62. PMID: 0009635027.

19.) Whang R, Whang DD, Ryan MP "Refractory potassium repletion. A consequence of magnesium deficiency" Arch Intern Med 1992, Vol 152 (1), Pg 40-5. PMID: 0001728927.

20.) Whyte KF, Addis GJ, Whitesmith R, Reid JL "Adrenergic control of plasma magnesium in man" Clin Sci 1987, Vol 72 (1), Pg 135-8. PMID: 0003542342.

21.) Dyckner T and Wester PO "Potassium/magnesium depletion in patients with cardiovascular disease" Am J Med 1987, Vol 82 (3A), Pg 11-7. PMID: 0003565422.

22-NA.) Lauler DP "Magnesium--coming of age" Am J Cardiol 1989, Vol 63 (14), Pg 1g-3g. PMID: 0002705371.

23.) Khaw KT and Barrett-Connor E "Dietary potassium and stroke-associated mortality. A 12-year prospective population study" N Engl J Med 1987, Vol 316 (5), Pg 235-40. PMID: 0003796701.

24-BK.) Leibovitz, B "Nutrition: At the Crossroads" in Morgenthaler, J and Fowkes, S "Stop the FDA: Save Your Health Freedom" Health Freedom Publications 1992, ISBN 0-9627418-8-4.

25.) Deuster PA, Dolev E, Kyle SB, Anderson RA, Schoomaker EB "Magnesium homeostasis during high-intensity anaerobic exercise in men" J Appl Physiol 1987, Vol 62 (2), Pg 545-50. PMID: 0003558215.

26.) Keen CL, Lowney P, Gershwin ME, Hurley LS, Stern JS "Dietary magnesium intake influences exercise capacity and hematologic parameters in rats" Metabolism 1987, Vol 36 (8), Pg 788-93. PMID: 0003600291.

27.) Stendig-Lindberg G, Shapiro Y, Epstein Y, Galun E, Schonberger E, Graff E, Wacker WE "Changes in serum magnesium concentration after strenuous exercise" J Am Coll Nutr 1987, Vol 6 (1), Pg 35-40. PMID: 0003453693.

28.) Geiss KR, Stergiou N, Jester, Neuenfeld HU, Jester HG "Effects of magnesium orotate on exercise tolerance in patients with coronary heart disease" Cardiovasc Drugs Ther 1998, Vol 12 Suppl 2 Pg 153-6. PMID: 0009794089.

29.) O'Keeffe S, Grimes H, Finn J, McMurrough P, Daly K "Effect of captopril therapy on lymphocyte potassium and magnesium concentrations in patients with congestive heart failure" Cardiology 1992, Vol 80 (2), Pg 100-5. PMID: 0001611628.

30.) Touyz RM "Magnesium supplementation as an adjuvant to synthetic calcium channel antagonists in the treatment of hypertension" Med Hypotheses 1991, Vol 36 (2), Pg 140-1. PMID: 0001664038.

31.) Stevenson RN, Keywood C, Amadi AA, Davies JR, Patterson DL "Angiotensin converting enzyme inhibitors and magnesium conservation in patients with congestive cardiac failure" Br Heart J 1991, Vol 66 (1), Pg 19-21. PMID: 0001854570.

32.) Haenni A, Berglund L, Reneland R, Anderssson PE, Lind L, Lithell H "The alterations in insulin sensitivity during angiotensin converting enzyme inhibitor treatment are related to changes in the calcium/magnesium balance" Am J Hypertens 1997, Vol 10 (2), Pg 145-51. PMID: 0009037321.

33.) Gottlieb SS, Baruch L, Kukin ML, Bernstein JL, Fisher ML, Packer M "Prognostic importance of the serum magnesium concentration in patients with congestive heart failure" J Am Coll Cardiol 1990, Vol 16 (4), Pg 827-31. PMID: 0002212365.

34-BK.) Pearson, D and Shaw, S "Life Extension : A Practical Scientific Approach" Warner Books 1987, ISBN 0446387355.

spacerg.gif (807 bytes)
spacerg.gif (807 bytes)