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Personally, I'm scared of Wellbutrin because of the risk of seizures -- especially if one takes high doses of the immediate release formula. The seizure frequency is about 0.4% (4/1000 patients) at doses of 300 to 450 mg a day. At doses between 450 mg and 600 mg a day, the seizure frequency is almost TENFOLD higher!!! The seizure frequency with the extended-release formulation is about 0.1% at doses of up to 300 mg a day, but it rises to about 0.4% at 400 mg a day (1-BK, 2). |
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Could you imagine what would happen if any supplement came within a hundred country miles of these adverse reaction rates?!? The FDA would be having seizures! And the mainstream media would convince the public that the Dietary Supplement Health and Education Act (DSHEA) had allowed a new black plague to descend upon us. Want to bet that --despite the statistics -- the FDA MedWatch report would blame ma huang (ephedrine) if someone had a seizure while combining Wellbutrin and thermogenic supplements?
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1-BK.) Harrison's Principles of Internal Medicine (CD version with the complete USP-DI.). 2.) Davidson J "Seizures and bupropion: a review" J Clin Psychiatry 1989, Vol 50 (7), Pg 256-61. PMID: 0002500425. |
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Is it safe to use an ECA stack if you are taking Wellbutrin?
I would not take ECA with Wellbutrin (bupropion). Although Wellbutrin has weak
noradrenaline reuptake blocking activity, it has an active metabolite, hydroxybupropion,
which may produce significant noradrenaline blockage (